Cov ua rau psoriasis cuam tshuam txog caj ces, tiv thaiv kab mob, ib puag ncig thiab lwm yam, thiab nws cov kab mob tseem tsis tau meej meej.
1. Cov yam ntxwv ntawm caj ces
Ntau cov kev tshawb fawb tau pom tias cov yam ntxwv ntawm caj ces ua lub luag haujlwm tseem ceeb hauv cov kab mob psoriasis. Tsev neeg keeb kwm ntawm tus kab mob no suav nrog 10% txog 23.8% ntawm cov neeg mob hauv Suav teb thiab kwv yees li 30% nyob rau txawv teb chaws.Qhov tshwm sim ntawm kev muaj menyuam yaus nrog psoriasis yog 2% yog tias niam txiv tsis muaj tus kabmob, 41% yog tias ob leeg niam txiv muaj tus kabmob, thiab 14% yog niam txiv muaj tus kabmob.Cov kev tshawb fawb ntawm cov menyuam ntxaib cuam tshuam nrog psoriasis tau pom tias cov menyuam ntxaib monozygotic muaj 72% qhov tshwm sim ntawm kev muaj tus kabmob tib lub sijhawm thiab cov menyuam ntxaib dizygotic muaj 30% qhov tshwm sim ntawm muaj tus kabmob tib lub sijhawm. Ntau tshaj 10 qhov hu ua susceptibility loci tau raug txheeb xyuas uas cuam tshuam nrog kev txhim kho ntawm psoriasis.
2. Kev tiv thaiv kab mob
Kev ua kom tsis zoo ntawm T-lymphocytes thiab infiltration nyob rau hauv lub epidermis los yog dermis yog ib qho tseem ceeb pathophysiological yam ntxwv ntawm psoriasis, qhia txog kev koom tes ntawm lub cev tiv thaiv kab mob nyob rau hauv kev loj hlob thiab kev loj hlob ntawm tus kab mob.Cov kev tshawb fawb tsis ntev los no tau pom tias IL-23 tsim los ntawm cov hlwb dendritic thiab lwm cov tshuaj tiv thaiv kab mob tam sim no (APCs) ua rau muaj kev sib txawv thiab kev loj hlob ntawm CD4 + pab T lymphocytes, Th17 hlwb, thiab sib txawv mature Th17 hlwb tuaj yeem tso ntau yam Th17-zoo li cellular yam xws li raws li IL-17, IL-21, thiab IL-22, uas txhawb kev loj hlob ntawm keratin-forming hlwb ntau dhau los yog inflammatory teb ntawm synovial hlwb. Yog li, Th17 hlwb thiab IL-23 / IL-17 axis tuaj yeem ua lub luag haujlwm tseem ceeb hauv cov kab mob psoriasis.
3. Ib puag ncig thiab Metabolic Factors
Ib puag ncig yam tseem ceeb ua lub luag haujlwm tseem ceeb hauv kev ua rau lossis ua rau mob hnyav dua psoriasis, lossis ua rau tus kab mob ntev, suav nrog kev kis kab mob, kev ntxhov siab ntawm lub hlwb, tus cwj pwm tsis zoo (xws li, haus luam yeeb, haus dej cawv), kev raug mob, thiab kev cuam tshuam rau qee yam tshuaj.Qhov pib ntawm pitting psoriasis feem ntau cuam tshuam nrog mob streptococcal kab mob ntawm lub pharynx, thiab kev kho mob los tiv thaiv kab mob tuaj yeem ua rau kev txhim kho thiab txo lossis tshem tawm ntawm daim tawv nqaij. Kev puas siab puas ntsws (xws li kev ntxhov siab, pw tsaug zog tsis zoo, ua haujlwm dhau) tuaj yeem ua rau psoriasis tshwm sim, hnyav dua lossis rov zoo dua, thiab kev siv cov lus qhia txog kev puas siab puas ntsws tuaj yeem txo qhov mob. Nws kuj tseem pom tau tias ntshav siab, ntshav qab zib mellitus, hyperlipidemia, kab mob plawv thiab tshwj xeeb tshaj yog cov kab mob metabolic muaj qhov tshwm sim ntawm cov neeg mob psoriasis.
Post lub sij hawm: Mar-17-2023
